SYNTHESIS OF N-SUBSTITUTED DERIVATIVES OF 2-(4-AMINO-2-METHYL-1H-INDOL-3-YL)- AND 2-(6-AMINO-2-METHYL-1H-INDOL-3-YL)ACETIC ACIDS

Authors

  • С. А. Маклаков D. I. Mendeleev Novomoskovsk Russian Chemical-Technological University, Novomoskovsk
  • Ю. И. Смушкевич D. I. Mendeleev Russian Chemical-Technological University, Moscow
  • И. В. Магедов K. A. Timiryazev Moscow Agricultural Academy, Moscow 127550

Keywords:

N-(3-hydrazinophenyl)acetamide, indole, indomethacin, Fischer reaction

Abstract

A method was developed for the production of indole compounds containing an amino group at positions 4 and 6 of the benzene ring on the basis of the indolization of the 3-acetylaminophenylhydrazone of ethyl levulinate. A series of derivatives of 2-(4-amino-2-methyl-1H-indol-3-yl)- and 2-(6-amino-2-methyl-1H-indol-3-yl)acetic acids at the 4- and 6-amino group were synthesized.

How to Cite
Maklakov, S. A.; Smushkevich, Yu. I.; Magedov, I. V. Chem. Heterocycl. Compd. 2002, 38, 904. [Khim. Geterotsikl. Soedin. 2002, 1043.]

For this article in the English edition, see DOI https://doi.org/10.1023/A:1020957110645

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Published

2002-08-25

Issue

No. 8 (2002)

Section

Original Papers