SILYL MODIFICATION OF BIOLOGICALLY ACTIVE COMPOUNDS. 8. TRIMETHYLSILYL ETHERS OF HYDROXYL-CONTAINING THIAZOLE DERIVATIVES

Authors

  • А. Заблоцкaя Latvian Institute of Organic Synthesis, Riga LV-1006
  • И. Сегaл Latvian Institute of Organic Synthesis, Riga LV-1006
  • C. Германе Latvian Institute of Organic Synthesis, Riga LV-1006
  • И. Шестакова Latvian Institute of Organic Synthesis, Riga LV-1006
  • И. Домрачева Latvian Institute of Organic Synthesis, Riga LV-1006
  • А. Нестерова Latvian Institute of Organic Synthesis, Riga LV-1006
  • А. Героникаки Department of Pharmaceutical Chemistry, Aristotelian University of Thessaloniki, 54006
  • Э. Лyкевиц Latvian Institute of Organic Synthesis, Riga LV-1006

Keywords:

piperidine, silyl group, thiazole, psychotropic activity, silylation, cytotoxicity

Abstract

Trimethylsilyl ethers of various hydroxyl-containing thiazole derivatives have been synthesized. The psychotropic activity (in vivo) and the cytotoxicity (in vitro on tumor cell lines HT-1080 and MG-22A) of these ethers and of their unsilylated precursors have been studied. It was discovered that the obtained compounds possess a sedative action. A moderate cytotoxic effect was detected for piperidine-containing thiazoles, displayed most strongly in relation to MG-22A cells.

How to Cite
Zablotskaya, A.; Segal, I.; Germane, S.; Shestakova, I.; Domracheva, I.; Nesterova, A.; Geronikaki, A.; Lukevics, E. Chem. Heterocycl. Compd. 2002, 38, 859. [Khim. Geterotsikl. Soedin. 2002, 968.]

For this article in the English edition, see DOI https://doi.org/10.1023/A:1020698107686

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Published

2002-07-25

Issue

No. 7 (2002)

Section

Original Papers