CONDENSED ISOQUINOLINES. 12. SYNTHESIS OF NOVEL HETEROCYCLIC SYSTEMS CONTAINING A PARTIALLY HYDROGENATED SPIRO[ISOQUINOLINE-4,4'-(2H)-PYRAN] FRAGMENT

Authors

  • B. M. Кисель Taras Shevchenko National University, Kiev 01033
  • E. O. Костырко Taras Shevchenko National University, Kiev 01033
  • M. O. Платонов Taras Shevchenko National University, Kiev 01033
  • B. А. Ковтуненко Taras Shevchenko National University, Kiev 01033

Keywords:

benzofuropyrimidine, isoquinoline, condensed isoquinolines, spirocyclic compounds, tetrahydropyran, thienopyrimidine, quinazoline

Abstract

By condensation of 4-(2-bromomethyl)-3,4,5,6-tetrahydro-2H-pyran-4-carbonitrile with anthranilic acid, its derivatives substituted in the benzene ring (esters, nitrile), and with esters of 2-aminothiophene-3-carboxylic acids and 3-amino-5-bromobenzofuran-2-carboxylic acid there have been synthesized novel derivatives which include spiro-linked tetrahydropyran and 5,10-dihydro-3H-pyrimido[1,2-b]isoquinoline fragments. The pyrimidine ring of the latter was annelated by a substituted benzene, thiophene, or 5-bromobenzofuran ring.

How to Cite
Kisel, V. M.; Kostyrko, E. O.; Platonov, M. O.; Kovtunenko, V. A. Chem. Heterocycl. Compd. 2002, 38, 300. [Khim. Geterotsikl. Soedin. 2002, 335.]

For this article in the English edition, see DOI https://doi.org/10.1023/A:1015683219884

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Published

2002-03-25

Issue

No. 3 (2002)

Section

Original Papers