SYNTHESIS OF 9-SUBSTITUTED DERIVATIVES OF 6-(NITROIMIDAZOLYL)THIOPURINES

Authors

  • Е. В. Александрова Zaporozhe State Medicinal University, Zaporozhe 330074
  • П. М. Кочергин Center for Medicinal Chemistry, All-Russian Chemical-Pharmaceutical Institute, Moscow 119815
  • Л. В. Персанова State Institute for Blood Replacement and Medicinal Preparations, Moscow 109044
  • В. С. Корсунский Center for Medicinal Chemistry, All-Russian Chemical-Pharmaceutical Institute, Moscow 119815
  • В. С. Шлихунова Center for Medicinal Chemistry, All-Russian Chemical-Pharmaceutical Institute, Moscow 119815

Keywords:

dimethylformamide, nitroimidazolylthiopurines, potassium carbonate, alkylation

Abstract

The synthesis has been achieved of a series of 9-substituted derivatives of 6-(4-nitroimidazol-5-yl)- and 6-(5-nitroimidazol-4-yl)thiopurines by the reaction of 6-(nitroimidazolyl)thiopurines with alkyl and aralkyl halides, haloalcohols, haloacids and their esters, halo ketones, halo aldehyde acetals, and arylsulfonate esters using potassium carbonate in DMF.

How to Cite
Aleksandrova, E. V.; Kochergin, P. M.; Persanova, L. V.; Korsunskii, V. S.; Shlikhunova, V. S. Chem. Heterocycl. Compd. 2001, 37, 610. [Khim. Geterotsikl. Soedin. 2001, 663.]

For this article in the English edition, see DOI https://doi.org/10.1023/A:1011612823352

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Published

2001-05-25

Issue

No. 5 (2001)

Section

Original Papers