4-AMINO-2-ARYL-3-CYANO-1,2-DIHYDROPYRIMIDO[1,2-<i>a</i>]BENZIMIDAZOLES AND THEIR PYRIMIDINE ANALOGS AS NEW ANTICANCER AGENTS

V. A. Risley; S. Henry; M. V. Kosyrikhina; M. R. Manzanares; I. Payan; C. D. Downer; C. C. Hellmann; S. Van Slambrouck; L. V. Frolova

doi:10.1007/1469

Авторы

V. A. Risley New Mexico Institute of Mining and Technology
S. Henry Mew Mexico Institute of Mining and Technology
M. V. Kosyrikhina School of Science, St. Thomas University
M. R. Manzanares School of Science, St. Thomas University
I. Payan School of Science, St. Thomas University
C. D. Downer School of Science, St. Thomas University
C. C. Hellmann School of Science, St. Thomas University
S. Van Slambrouck School of Science, St. Thomas University
L. V. Frolova Mew Mexico Institute of Mining and Technology

DOI:

https://doi.org/10.1007/1469

Ключевые слова:

benzimidazole, 1, 2-dihydropyrimidine, 2-dihydropyrimido[1, 2-a]benzimidazoles, pyrimidine, pyrimido[2, 1-a]benzimidazoles, anticancer activity, multicomponent reactions

Аннотация

A multicomponent condensation between 2-aminobenzimidazole, malononitrile, and an aryl or heteroaryl aldehyde was used for the synthesis of 4-amino-2-aryl-3-cyano-1,2-dihydropyrimido[1,2-a]benzimidazoles. In addition, a new method of synthesis of corresponding pyrimido[2,1-a]benzimidazole derivatives was developed. These syntheses were used to prepare a library of 4-amino-2-aryl-3-cyano-1,2-dihydropyrimido[1,2-a]benzimidazoles and their corresponding pyrimido[2,1-a]benzimidazole derivatives. This library of compounds was then tested against pancreatic and breast cancer cell lines. A number of compounds were found to possess notable anticancer activity.

Биографии авторов

V. A. Risley, New Mexico Institute of Mining and Technology

undergraduate student, Department of Chemistry