SYNTHESIS OF 4-AZAPODOPHYLLOTOXINS WITH ANTICANCER ACTIVITY BY MULTICOMPONENT REACTIONS

Аннотация

In the last 13 years, considerable advances have been made in the development of 4-azapodophyllotoxins as anticancer agents. The current review covers this research with an emphasis on the synthesis of less stereochemically complex podophyllotoxin analogs by efficient multicomponent reactions. After a short introduction to the 4-azapodophyllotoxins prepared by such reactions, the debate concerning their exact mechanisms is highlighted. This is followed by a description of 4-azapodophyllotoxin libraries and a discussion of their documented anticancer activities. The review concludes with an analysis of the proposed mode of action and future directions in this fascinating area of research.