THREE-COMPONENT SYNTHESIS OF 4-AROYL-2(1),4,5,7-TETRAHYDROPYRAZOLO[3,4-<i>b</i>]PYRIDIN-6-ONES AND THEIR PROPERTIES

Авторы

  • O. N. Petrova State Scientific Institution "Institute for Single Crystals" of National Academy of Sciences of Ukraine
  • L. L. Zamigajlo State Scientific Institution "Institute for Single Crystals" of National Academy of Sciences of Ukraine
  • I. M. Gella State Scientific Institution "Institute for Single Crystals" of National Academy of Sciences of Ukraine; V. N. Karazin Kharkiv National University
  • V. I. Musatov State Scientific Institution "Institute for Single Crystals" of National Academy of Sciences of Ukraine
  • S. V. Shishkina State Scientific Institution "Institute for Single Crystals" of National Academy of Sciences of Ukraine
  • O. V. Shishkin State Scientific Institution "Institute for Single Crystals" of National Academy of Sciences of Ukraine; V. N. Karazin Kharkiv National University
  • E. V. Vashchenko State Scientific Institution "Institute for Single Crystals" of National Academy of Sciences of Ukraine
  • A. V. Borisov Enamine Ltd.
  • V. V. Lipson State Scientific Institution "Institute for Single Crystals" of National Academy of Sciences of Ukraine; V. N. Karazin Kharkiv National University; Antidiabetic Drug Laboratory, SI "V. Ya. Danilevsky Institute for Endocrine Pathology Problems"

DOI:

https://doi.org/10.1007/1641

Ключевые слова:

5-aminopyrazoles, arylglyoxals, Meldrum's acid, tetrahydropyrazolo[3, 4-b]pyridines, acylation, alkylation, oxidation, reduction, three-component reaction

Аннотация

Inspired by the concept of multicomponent reactions, a novel one-pot synthesis involving arylglyoxals, 5-aminopyrazoles, and Meldrum's acid has been developed and employed for the creation of a small library of 4‑aroyl-2(1),4,5,7‑tetrahydro­pyrazolo­[3,4‑b]­pyridin-6-ones. The alkylation, acylation, reduction, and oxidation reactions of 4‑aroyl-3‑methyl-2,4,5,7-tetrahydropyrazolo[3,4-b]pyridin-6-ones have been studied.

How to Cite
Petrova, O. N.; Zamigajlo, L. L.; Gella, I. M.; Musatov, V. I.; Shishkina, S. V.; Shishkin, O. V.; Vashchenko, E. V.; Borisov, A. V.; Lipson, V. V. Chem. Heterocycl. Compd. 2014, 50, 514. [Khim. Geterotsikl. Soedin. 2014, 562.]

For this article in the English edition see DOI 10.1007/s10593-014-1502-7

Загрузки

Опубликован

2014-05-06

Выпуск

№ 4 (2014)

Раздел

Оригинальные статьи