SYNTHESIS AND POTENT CYTOTOXICITY OF SOME NOVEL IMIDAZOPYRIDINE DERIVATIVES AGAINST MCF-7 HUMAN BREAST ADENOCARCINOMA CELL LINE

Авторы

  • Mustafa Orhan Püsküllü Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Erciyes University, 38039 Kayseri
  • Cigdem Karaaslan Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Ankara University, 06100 Tandogan, Ankara
  • Filiz Bakar Department of Biochemistry, Faculty of Pharmacy, Ankara University, 06100 Tandogan, Ankara
  • Hakan Goker Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Ankara University, 06100 Tandogan, Ankara

DOI:

https://doi.org/10.1007/2282

Ключевые слова:

carboxamidine, 3H-imidazo[4, 5-b]pyridine, 5-c]pyridine, MCF-7 cell line, cytotoxicity, steric hindrance

Аннотация

A series of novel 2-phenyl-3H-imidazo[4,5-b]pyridines and 2-phenyl-3H-imidazo[4,5-c]pyridines and their precursors were synthesized. Their in vitro cytotoxicity against MCF-7 human breast adenocarcinoma cell line has been investigated, and some of the tested compounds have shown high cytotoxic activity against MCF-7 cells. N-Hydroxy-4-(3H-imidazo[4,5-b]pyridin-2-yl)benzenecarboximidamide was the most active compound with IC50 equal to 0.082 μM, which is an activity almost as high as that of a commonly used anticancer drugs docetaxel and imatinib mesylate.

How to Cite
Püsküllü, M. O.; Karaaslan, C.; Bakar, F.; Göker, H. Chem. Heterocycl. Compd. 2015, 51, 723. [Khim. Geterotsikl. Soedin. 2015, 51, 723.]

For this article in the English edition see DOI 10.1007/s10593-015-1765-7

Биографии авторов

Mustafa Orhan Püsküllü, Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Erciyes University, 38039 Kayseri

Erciyes University, School of Pharmacy, Department of Pharmaceutical Chemistry

Cigdem Karaaslan, Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Ankara University, 06100 Tandogan, Ankara

Research Assistant Ph.D.,
Ankara University, Faculty of Pharmacy,
Department of Pharmaceutical Chemistry

Filiz Bakar, Department of Biochemistry, Faculty of Pharmacy, Ankara University, 06100 Tandogan, Ankara

Assistant Professor, Ankara University, Faculty of Pharmacy,
Department of Biochemistry

Hakan Goker, Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Ankara University, 06100 Tandogan, Ankara

Prof. Dr., Ankara University, Faculty of Pharmacy, Department of Pharmaceutical Chemistry

Загрузки

Опубликован

2015-09-11

Выпуск

Том 51 № 8 (2015)

Раздел

Оригинальные статьи