MICROWAVE-ASSISTED SYNTHESIS AND ANTIMICROBIAL EVALUATION OF NOVEL PYRAZOLINES

Авторы

  • Ashok Dongamanti Department of Chemistry, Osmania University, Tamaka, Hyderabad 500 007
  • Mohan Gandhi Devulapally Department of Chemistry, Osmania University, Tamaka, Hyderabad 500 007
  • Vikas Kumar Aamate Department of Chemistry, Osmania University, Tamaka, Hyderabad 500 007
  • Srinivas Gundu Department of Chemistry, Osmania University, Tamaka, Hyderabad 500 007

DOI:

https://doi.org/10.1007/2356

Ключевые слова:

antimicrobial activity, chalcones, Michael addition, microwave irradiation, pyrazolines

Аннотация

A series of 6-(5-aryl-4,5-dihydro-1H-pyrazol-3-yl)-2,2-dimethylchroman-7-ol and 6-(5-aryl-4,5-dihydro-1H-pyrazol-3-yl)-2,2-dimethylchroman-5-ol derivatives have been synthesized from the corresponding chalcones and hydrazine hydrate in the presence of sodium acetate under microwave irradiation involving the Michael addition followed by cycloaddition. All the newly synthesized 18 compounds were screened for their in vitro antimicrobial activity. Most of the compounds displayed very good to excellent antimicrobial activity in comparison to standard drugs streptomycin and nystatin.

How to Cite
Dongamanti, A.; Devulapally, M. G.; Aamate, V. K.; Gundu, S. Chem. Heterocycl. Compd. 2015, 51, 872. [Khim. Geterotsikl. Soedin. 2015, 51, 872.]

For this article in the English edition see DOI 10.1007/s10593-015-1790-6

Загрузки

Опубликован

2015-10-29

Выпуск

Том 51 № 10 (2015)

Раздел

Оригинальные статьи