PRIVILEGED HETEROCYCLES: BIOACTIVITY AND SYNTHESIS OF 1,9-DIAZASPIRO[5.5]UNDECANE-CONTAINING COMPOUNDS

Авторы

  • Daniel Blanco-Ania Radboud University, Institute for Molecules and Materials, Heyendaalseweg 135, 6526 AJ Nijmegen
  • Rik Heus Radboud University, Institute for Molecules and Materials, Heyendaalseweg 135, 6526 AJ Nijmegen
  • Floris P. J. T. Rutjes Radboud University, Institute for Molecules and Materials, Heyendaalseweg 135, 6526 AJ Nijmegen

DOI:

https://doi.org/10.1007/3874

Ключевые слова:

1, 9-diazaspiro[5.5]undecane, 9-diazaspiro[5.5]undecan-2-one, spiro dipiperidines, obesity, pain treatment

Аннотация

This review discusses the biological activity and synthesis of 1,9-diazaspiro[5.5]undecanes, including those ring-fused with arenes and heteroarenes and/or containing a carbonyl group at position 2. These compounds could be used for the treatment of obesity, pain, as well as various immune system, cell signaling, cardiovascular, and psychotic disorders.

Загрузки

Опубликован

2017-10-03

Выпуск

Том 53 № 8 (2017)

Раздел

Обзорные статьи