METHYLATION OF IMIDAZOPYRAZINE, IMIDAZOQUINOXALINE, AND PYRAZOLOQUINOXALINE THROUGH SUZUKI–MIYAURA CROSS COUPLING

Авторы

  • Nour Bou Karroum IBMM, Université de Montpellier, CNRS, ENSCM, Montpellier
  • Cindy Patinote Société d’Accélération du Transfert de Technologies (SATT AxLR), CSU, 950 rue Saint Priest, 34090 Montpellier
  • Carine Deleuze-Masquefa IBMM, Université de Montpellier, CNRS, ENSCM, Montpellier
  • Georges Moarbess Tumorigenèse et Pharmacologie Antitumorale, Lebanese University, EDST, BP 90656, Fanar Jdeideh
  • Mona Diab-Assaf Tumorigenèse et Pharmacologie Antitumorale, Lebanese University, EDST, BP 90656, Fanar Jdeideh
  • Pierre Cuq IBMM, Université de Montpellier, CNRS, ENSCM, Montpellier
  • Issam Kassab Tumorigenèse et Pharmacologie Antitumorale, Lebanese University, EDST, BP 90656, Fanar Jdeideh
  • Pierre Antoine Bonnet IBMM, Université de Montpellier, CNRS, ENSCM, Montpellier

DOI:

https://doi.org/10.1007/4177

Ключевые слова:

imidazo[1, 2-a]pyrazine, 2-a]quinoxaline, pyrazolo[1, 5-a]quinoxaline, methylation, Suzuki–Miyaura cross coupling

Аннотация

The Suzuki–Miyaura cross coupling is a versatile and powerful reaction for carbon–carbon bond formation which nevertheless requires optimization of conditions. While the coupling of arylboron derivatives with aryl or alkenyl halides has been widely explored, alkylation has attracted less attention. We describe herein the methylation of bromo derivatives of imidazopyrazine, imidazoquinoxaline, and pyrazoloquinoxaline having biologically interesting structures. As the challenging Suzuki–Miyaura reaction is highly substratedependent, the choices of the base, solvent, and additive are also discussed.

Биографии авторов

Nour Bou Karroum, IBMM, Université de Montpellier, CNRS, ENSCM, Montpellier

IBMM

Carine Deleuze-Masquefa, IBMM, Université de Montpellier, CNRS, ENSCM, Montpellier

IBMM

Pierre Cuq, IBMM, Université de Montpellier, CNRS, ENSCM, Montpellier

IBMM

Pierre Antoine Bonnet, IBMM, Université de Montpellier, CNRS, ENSCM, Montpellier

IBMM

Загрузки

Опубликован

2018-03-27

Выпуск

Том 54 № 2 (2018)

Раздел

Оригинальные статьи