USE OF HYPERVALENT IODINE IN THE SYNTHESIS OF ISOMERIC DIHYDROOXAZOLES

Авторы

  • Claudia Carlucci Flow Chemistry and Microreactor Technology Laboratory (FLAME-Lab), Department of Pharmacy – Pharmaceutical Sciences, University of Bari Aldo Moro, Via E. Orabona 4, Bari 70125
  • Arianna Tota Flow Chemistry and Microreactor Technology Laboratory (FLAME-Lab), Department of Pharmacy – Pharmaceutical Sciences, University of Bari Aldo Moro, Via E. Orabona 4, Bari 70125
  • Marco Colella Flow Chemistry and Microreactor Technology Laboratory (FLAME-Lab), Department of Pharmacy – Pharmaceutical Sciences, University of Bari Aldo Moro, Via E. Orabona 4, Bari 70125
  • Giuseppe Romanazzi DICATECh, Politecnico di Bari, Via E. Orabona 4, Bari 70125
  • Guy J. Clarkson Department of Chemistry, University of Warwick, Gibbet Hill Road, Coventry CV4 7AL
  • Renzo Luisi Flow Chemistry and Microreactor Technology Laboratory (FLAME-Lab), Department of Pharmacy – Pharmaceutical Sciences, University of Bari Aldo Moro, Via E. Orabona 4, Bari 70125
  • Leonardo Degennaro Flow Chemistry and Microreactor Technology Laboratory (FLAME-Lab), Department of Pharmacy – Pharmaceutical Sciences, University of Bari Aldo Moro, Via E. Orabona 4, Bari 70125

DOI:

https://doi.org/10.1007/4436

Ключевые слова:

hypervalent iodine, 2-oxazolines, 3-oxazolines, NMR studies, stereoselective synthesis

Аннотация

A convenient synthesis of 2- and/or 3-oxazolines has been developed depending on the structure and stereochemistry of the starting amino alcohol. PhI(OAc)2 acted as oxidant on the intermediate imine, as supported by NMR investigation. The findings demonstrate a new route providing access to unusual 3-oxazolines.

Загрузки

Опубликован

2018-06-05

Выпуск

Том 54 № 4 (2018): Стереоселективный синтез гетероциклических соединений

Раздел

Оригинальные статьи