ONE-POT SYNTHESIS OF <i>N</i>-(PHOSPHORYLMETHYL)PYRROLIDINES <i>VIA</i> ACID-CATALYZED CASCADE ELIMINATION/CYCLIZATION/FRIEDEL–CRAFTS REACTION
DOI:
https://doi.org/10.1007/5523Ключевые слова:
aminophosphonate, pyrrolidine, cyclization, heterocycle.Аннотация
The efficient approach to novel water-soluble 2-aryl-substituted N-(phosphorylmethyl)pyrrolidines via acid-catalyzed elimination/cyclization/Friedel–Crafts reaction sequence of {[(4,4-diethoxybutyl)amino]methyl}phosphonates is proposed. Zwitterionic structure of N-(phosphorylmethyl)pyrrolidines has been proved by X-ray crystallography.
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Опубликован
2020-05-28
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Оригинальные статьи