ALIPHATIC CHAIN-CONTAINING MACROCYCLES AS DIAZONAMIDE A ANALOGS
DOI:
https://doi.org/10.1007/5534Ключевые слова:
diazonamide A, anticancer agents, macrocycles, ring-closing metathesis.Аннотация
Aliphatic alkyl chain-containing 12–14-membered macrocycles have been designed as structural analogs of antimitotic natural product diazonamide A. Macrocycles were synthesized from 5-bromooxazole in 7 to 9 linear steps using Ru-catalyzed ring-closing metathesis as the key transformation. Heat effect of binding to α,β-tubulin tetramer (T4-RB3 complex) has been measured for the synthesized macrocycles by isothermal titration calorimetry method.Загрузки
Опубликован
2020-05-28
Выпуск
Раздел
Оригинальные статьи