A SINGLE-STEP SYNTHESIS OF XYRIDINS A AND B, METABOLITES FROM <i>Xyris indica</i>
DOI:
https://doi.org/10.1007/8209Ключевые слова:
isocoumarins, xyridin A, xyridin B, Xyris indica, diastereotopy, mass fragmentationАннотация
A facile single step synthesis of the title isocoumarins isolated from Xyris indica has been elaborated. Condensation of butanoyl chloride and 2-oxobutanoyl chloride with 3,4-methylene-
dioxyhomophthalic acid afforded xyridin A and xyridin B, respectively. Xyridin A was saponified to corresponding keto acid which on reduction gave the (±)-3,4-dihydro-6,7-methylenedioxy-3-propylisocoumarin in which diastereotopy of the methylenic protons around the stereogenic centre was observed. Mass fragmentation mechanism for xyridins has also been suggested.
How to Cite
Saeed, A. Chem. Heterocycl. Compd. 2005, 41, 967. [Khim. Geterotsikl. Soedin. 2005, 1140.]
For this article in the English edition, see DOI 10.1007/s10593-005-0262-9
