STUDIES ON PYRAZINE DERIVATIVES. 38. SYNTHESIS, REACTIONS, AND TUBERCULOSTATIC ACTIVITY OF PYRAZINYL-SUBSTITUTED DERIVATIVES OF HYDRAZINOCARBODITHIOIC ACID

Авторы

  • H. Foks Department of Organic Chemistry Medical University of Gdańsk 80-416 Gdańsk
  • I. Trapkowska Department of Organic Chemistry Medical University of Gdańsk 80-416 Gdańsk
  • M. Janowiec Department of Microbiology Institute of Tuberculosis and Pulmonary Diseases 01-138 Warszawa
  • Z. Zwolska Department of Microbiology Institute of Tuberculosis and Pulmonary Diseases 01-138 Warszawa
  • E. Augustynowicz-Kopeć Department of Microbiology Institute of Tuberculosis and Pulmonary Diseases 01-138 Warszawa

Ключевые слова:

6-chloro-2-cyanopyrazine, amidrazones, mono- and diesters of hydrazinocarbodithioic acids, imino esters, 1,3,4-thiadiazole-2-thiol, 1,2,4-triazoles, carbon disulfide, tuberculostatics

Аннотация

The synthesis of N'-[amino(6-chloro- and 6-cycloaminopyrazin-2-yl)methylene]carbodithioic acid mono- and diesters and their reactions are described. Cyclization of monoesters with secondary amines in acidic media gave the 1,3,4-thiadiazole derivatives, while the cyclization of diesters with amines yielded 1,2,4-triazoles with amine substituent in position 3. The in vitro tuberculostatic activity of the prepared compounds was tested.

How to Cite
Foks, H.; Trapkowska, I.; Janowiec, M.; Zwolska, Z.; Augustynowicz-Kopeć, E. Chem. Heterocycl. Compd. 2004, 40, 1185. [Khim. Geterotsikl. Soedin. 2004, 1368.]

For this article in the English edition, see DOI 10.1023/B:COHC.0000048293.68655.d5

Загрузки

Опубликован

2004-09-25

Выпуск

№ 9 (2004)

Раздел

Оригинальные статьи