FORMYLATION OF PYRROLO[1,2-<i>a</i>]PYRAZINES
DOI:
https://doi.org/10.1007/6940Keywords:
pyrrolo[1, 2-a]pyrazine, formylation, electrophilic substitution, Vilsmeier-Haack reactionAbstract
The formylation of pyrrolo[1,2-a]pyrazines containing alkyl, aryl, or hetaryl substituents in positions 1 and 6 of the heterocycle has been studied. It has been shown that formylation of 1-phenyl- and 1-(2 thienyl)pyrrolo[1,2-a]pyrazine occurs selectively at the α-position of the pyrrole ring. In all of the remaining examples the reaction course depends on substituent, reagent ratio, and reaction time.
How to Cite
Terenin, V. I.; Butkevich, M. A.; Ivanov, A. S.; Tselischeva, N. A.; Kabanova, E. V. Chem. Heterocycl. Compd. 2008, 44, 73. [Khim. Geterotsikl. Soedin. 2008, 88.]
For this article in the English edition see DOI 10.1007/s10593-008-0010-z