FORMYLATION OF PYRROLO[1,2-<i>a</i>]PYRAZINES

Authors

  • В. И. Теренин M. V. Lomonosov Moscow State University, Moscow 119992
  • М. А. Буткевич M. V. Lomonosov Moscow State University, Moscow 119992
  • А. C. Иванов M. V. Lomonosov Moscow State University, Moscow 119992
  • Н. А. Целищева M. V. Lomonosov Moscow State University, Moscow 119992
  • Е. В. Кабанова M. V. Lomonosov Moscow State University, Moscow 119992

DOI:

https://doi.org/10.1007/6940

Keywords:

pyrrolo[1, 2-a]pyrazine, formylation, electrophilic substitution, Vilsmeier-Haack reaction

Abstract

The formylation of  pyrrolo[1,2-a]pyrazines  containing alkyl, aryl, or hetaryl substituents in positions 1 and 6 of the heterocycle has been  studied.  It  has been shown that formylation of 1-phenyl- and 1-(2 thienyl)pyrrolo[1,2-a]pyrazine occurs selectively at the α-position of the pyrrole ring. In all of the remaining examples the reaction course depends on substituent, reagent ratio, and reaction time.

How to Cite
Terenin, V. I.; Butkevich, M. A.; Ivanov, A. S.; Tselischeva, N. A.; Kabanova, E. V.  Chem. Heterocycl. Compd. 2008, 44, 73. [Khim. Geterotsikl. Soedin. 2008, 88.]

For this article in the English edition see DOI 10.1007/s10593-008-0010-z

 

Downloads

Published

2022-08-04

Issue

No. 1 (2008)

Section

Original Papers