Synthesis of pyrido[3′,2′:4,5]thieno[2,3-<i>c</i>]cinnolines — A new heterocyclic system

Authors

  • B. А. Артемов N. D. Zelinskii Institute of Organic Chemistry, Russian Academy of Sciences, 117913 Moscow
  • B. Л. Иванов N. D. Zelinskii Institute of Organic Chemistry, Russian Academy of Sciences, 117913 Moscow
  • А. B. Кошкаров N. D. Zelinskii Institute of Organic Chemistry, Russian Academy of Sciences, 117913 Moscow
  • А. M. Шестопалов N. D. Zelinskii Institute of Organic Chemistry, Russian Academy of Sciences, 117913 Moscow
  • B. П. Литвинов N. D. Zelinskii Institute of Organic Chemistry, Russian Academy of Sciences, 117913 Moscow

Abstract

Pyrido[3′,2′:4,5]thieno[2,3-c]cinnolines, new heterocyclic compounds, were obtained in three steps: 1) alkylation of 3-cyanopyridine-2(1H)-thiones by o-nitrobenzyl bromide to give 2-(o-nitrobenzyl)thio-3-cyanopyridines, 2) closure of the thiophene ring in these intermediates to give 3-amino-2-(o-nitrophenyl)thieno[2,3-b]pyridines, and 3) closure of the pyridazine ring by condensation of the amino and nitro groups in triethyl phosphite, leading to the final heterocyclic system.

How to Cite
Artemov, V. A.; Ivanov, V. L.; Koshkarov, A. V.; Shestopalov, A. M.; Litvinov, V. P. Chem. Heterocycl. Compd. 1998, 34, 96. [Khim. Geterotsikl. Soedin. 1998, 34, 104.]

For this article in the English edition, see DOI https://doi.org/10.1007/BF02290619

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Published

1998-01-25

Issue

No. 1 (1998)

Section

Original Papers