Steric effects in the synthesis of pyrroloindoles from 5-aminoindoles

Abstract

The formation of angular pyrroindoles from 5-aminoindole substitued in the pyrrole ring depends both on the steric requirements of the substituent at the β-position of the pyrrole ring, and on the structure of the α-hydroxyketone. Significant amounts of the angular pyrroloindole are only formed together with the linear pyrroindole in the reaction of 2-methyl-5-aminoindole with benzoin. In the remaining cases, the linear ring closure of the pyrrole ring predominates.

How to Cite
Yamashkin, S. A. Chem. Heterocycl. Compd. 1995, 31, 47. [Khim. Geterotsikl. Soedin. 1995, 55.]

For this article in the English edition, see DOI https://doi.org/10.1007/BF01171289