A CONVENIENT ROUTE TO CYANO DERIVATIVES OF BENZONAPHTHYRIDINES

Abstract

A smooth synthesis of benzo[c][1,5]naphtyridine-6-carbonitrile and benzo[h][1,6]naphthyridine-5-carbonitrile, starting from benzonaphthyridine N-oxides, is achieved by treatment with trimethylsilane carbonitrile (Me₃SiCN) in CH₂Cl₂ at 0–5°C. The resulting nitriles are then hydrolyzed to corresponding acids by boiling in aqueous alkali.

How to Cite
Bachowska, B. Chem. Heterocycl. Compd. 2011, 47(3), 332. [Khim. Geterotsikl. Soedin. 2011, 406.]

For this article in the English edition see DOI 10.1007/s10593-011-0761-9