STRUCTURAL ANALOGS OF UMIFENOVIR 2*. THE SYNTHESIS AND ANTIHIV ACTIVITY STUDY OF NEW REGIOISOMERIC (<i>trans</i>-2-PHENYLCYCLOPROPYL)-1<i>Н</i>-INDOLE DERIVATIVES
DOI:
https://doi.org/10.1007/2732Keywords:
umifenovir, conformationally restricted analogs, antiviral activityAbstract
We report new carboanalogs of umifenovir – regioisomeric derivatives of ethyl 5-hydroxy-(trans-2-phenylcyclopropyl)-1Н-indole-3carboxylate. The inhibition of HIV replication by umifenovir and its carboanalogs at micromolar concentration range has been demonstrated for the first time.
How to Cite
Schols, D.; Ruchko, E. A.; Lavrenov, S. N.; Kachala, V. V.; Nawrozkij, M. B.; Babushkin, A. S. Chem. Heterocycl. Compd. 2015, 51, 978. [Khim. Geterotsikl. Soedin. 2015, 51, 978.]
For this article in the English edition see DOI 10.1007/s10593-016-1807-9