PYRROLO[2,3-<i>d</i>]PYRIMIDINE DERIVATIVES IN THE SYNTHESIS OF A NOVEL HETEROCYCLIC SYSTEM 2a,5a,7-TRIAZAACENAPHTHYLENE

Authors

  • Любовь B. Музычка V. P. Kukhar Institute of Bioorganic Chemistry and Petrochemistry, National Academy of Sciences of Ukraine, 1 Murmanska St., Kyiv 02094
  • Ирина O. Яремчук V. P. Kukhar Institute of Bioorganic Chemistry and Petrochemistry, National Academy of Sciences of Ukraine, 1 Murmanska St., Kyiv 02094
  • Евгений B. Вервес V. P. Kukhar Institute of Bioorganic Chemistry and Petrochemistry, National Academy of Sciences of Ukraine, 1 Murmanska St., Kyiv 02094
  • Олег Б. Смолий V. P. Kukhar Institute of Bioorganic Chemistry and Petrochemistry, National Academy of Sciences of Ukraine, 1 Murmanska St., Kyiv 02094

DOI:

https://doi.org/10.1007/5009

Keywords:

pyrimido[5', 4', 4, 5]pyrrolo[2, 1-c][1, 4]oxazine, pyrrolo[2, 3-d]pyrimidine, 2a, 5a, 7-triazaacenaphthylene, cyclization, iodination

Abstract

A convenient method for the synthesis of methyl 8-oxo-3H,8H-2a,5a,7-triazaacenaphthylene-2-carboxylate by iodination of 7-allyl-4-methoxypyrrolo[2,3-d]pyrimidine-6-carboxylic acid methyl ester followed by elimination of hydrogen iodide has been developed. The use of 4-methoxypyrrolo[2,3-d]pyrimidine-6-carboxylic acid as the starting compound led to the formation of iodomethylpyrimido[5',4':4,5]pyrrolo[2,1-c][1,4]oxazine, a promising precursor for the synthesis of a new tricyclic system based on pyrrolo[2,3-d]pyrimidine.

Authors: Lyubov V. Muzychka, Iryna O. Yaremchuk, Evgenii V. Verves, Oleg B. Smolii*

Author Biography

Олег Б. Смолий, V. P. Kukhar Institute of Bioorganic Chemistry and Petrochemistry, National Academy of Sciences of Ukraine, 1 Murmanska St., Kyiv 02094

Олег Борисович Смолий

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Published

2019-05-22

Issue

Vol. 55 No. 4/5 (2019): In memory of Professor Valerii Dmitrievich Orlov

Section

Original Papers