SYNTHESIS OF 3-O-ARYL ESTERS OF (<i>R</i>,<i>S</i>)-9-(2,3-DIHYDROXYPROPYL)ADENINE AND ITS PYRIMIDINE ANALOGS AS NEW POTENTIAL INHIBITORS OF <i>S</i>-ADENOSYL-<i>L</i>-HOMOCYSTEINE HYDROLASE

Abstract

With the aim of searching for new antiviral agents of the acyclonucleoside type, 3-O-aryl esters of (R,S)-9-(2,3-dihydroxypropyl)adenine and its pyrimidine analogs have been synthesized. Alkylation of adenine and cytosine by aryl glycidyl ethers in the presence of potassium carbonate affords 46-76% yields of the corresponding N9- and N1-substituted derivatives. The interaction of aryl glycidyl ethers with trimethylsilyl derivatives of uracil and thymine also results in 41-57% yields of N1-monosubstituted products with identical acyclic chain structure.

Authors: A. A. Ozerov, M. S. Novikov, and A. K. Brel’.

English Translation in Chemistry of Heterocyclic Compounds, 1999, 35 (1), pp 78-83

http://link.springer.com/article/10.1007/BF02251667