SYNTHESIS OF <i>N</i>-BENZYLIDENE- AND <i>N</i>-ALKYLIDENE(3,3-DIALKYL-3,4-DIHYDROISOQUINOLIN-1(2<i>H</i>)-YLIDENE)ACETOHYDRAZIDES <i>VIA</i> THE RITTER REACTION
Authors
Александр Г. Михайловский
Perm State Pharmaceutical Academy,
2 Polevaya St., Perm 614990, Russia
Евгения C. Погорелова
Perm State Pharmaceutical Academy,
2 Polevaya St., Perm 614990, Russia
Наталия Н. Першина
Perm State Pharmaceutical Academy,
2 Polevaya St., Perm 614990, Russia
The Ritter cyclocondensation of 2-methyl-1-phenylpropan-2-ols with cyanoacetohydrazide hydrazones in PhMe–H2SO4 medium at 60–70°С for 20 min resulted in the formation of N-benzylidene- and N-alkylidene(3,3-dialkyl-3,4-dihydroisoquinolin-1(2H)-ylidene)acetohydrazides. The product of β-C-carbamoylation of the enamine moiety was also obtained.
Author Biographies
Александр Г. Михайловский, Perm State Pharmaceutical Academy,
2 Polevaya St., Perm 614990, Russia
The chief of department for general chemistry, professor
Евгения C. Погорелова, Perm State Pharmaceutical Academy,
2 Polevaya St., Perm 614990, Russia
аспирант кафедры общей и органической химии
Наталия Н. Першина, Perm State Pharmaceutical Academy,
2 Polevaya St., Perm 614990, Russia
