4-HYDROXY-2-QUINOLONES. 141. SYNTHESIS AND STRUCTURE OF 5R-3-HYDROXY-1,5-DIHYDROPYRAZOLO[4,3-<i>c</i>]QUINOLIN-4-ONES

Authors

  • И. В. Украинец National University of Pharmacy, Kharkiv 61002
  • В. В. Кравцова National University of Pharmacy, Kharkiv 61002
  • А. А. Ткач National University of Pharmacy, Kharkiv 61002
  • Г. Сим Far Eastern State Medical University, Khabarovsk 680000

DOI:

https://doi.org/10.1007/6970

Keywords:

1, 5-dihydropyrazolo[4, 3-c]quinolin-4-ones, 4-chloro-2-oxo-1, 2-dihydroquinolines, p-toluenesulfonylhydrazide, X-ray structural analysis

Abstract

Treatment of 1R-4-chloro-3-ethoxycarbonyl-2-oxo-1,2-dihydroquinolines with p-toluenesulfonyl-hydrazide in refluxing ethanol and in the presence  of triethylamine gives the 3-hydroxy-5R-1,5-dihydropyrazolo[4,3-c]quinolin-4-ones. The possible mechanism of formation, features of the steric structure of the synthesized compounds, and their NMR and mass spectra are discussed.

How to Cite
Ukrainets, I. V.; Kravtsova, V. V.; Tkach, A. A.; Sim, G.  Chem. Heterocycl. Compd. 2008, 44, 173. [Khim. Geterotsikl. Soedin. 2008, 233.]

For this article in the English edition see DOI 10.1007/s10593-008-0032-6


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Published

2022-08-10

Issue

No. 2 (2008)

Section

Original Papers