4-HYDROXY-2-QUINOLONES. 120. SYNTHESIS AND STRUCTURE OF ETHYL 2-HYDROXY-4-OXO-4H-PYRIDO[1,2-<i>a</i>]PYRIMIDINE-3-CARBOXYLATE

Authors

  • И. В. Украинец National University of Pharmacy, Kharkiv 61002
  • Н. Л. Березнякова National University of Pharmacy, Kharkiv 61002
  • Г. П. Петюнин National University of Pharmacy, Kharkiv 61002
  • И. А. Тугайбей National University of Pharmacy, Kharkiv 61002
  • В. Б. Рыбаков M. V. Lomonosov Moscow State University, Moscow 119899
  • В. В. Чернышев M. V. Lomonosov Moscow State University, Moscow 119899
  • А. В. Туров Taras Shevchenko National University, Kiev 01033

DOI:

https://doi.org/10.1007/7497

Keywords:

2-aminopyridines, heterocyclic tricarbonylmethane derivatives, 2-hydroxy-4-oxo-4H-pyrido[1, 2-a]pyrimidine-3-carboxylic acids, esters, X-ray analysis

Abstract

An improved method for the preparation and purification of ethyl 2-hydroxy-4-oxo-4H-pyrido[1,2-a]-pyrimidine-3-carboxylates is proposed. According to  1H and  13C NMR spectroscopic data the synthesized compounds exist in DMSO solution in the 2-hydroxy-4-oxo form while in the crystal (at least for the case of the unsubstituted derivative) X-ray analysis shows that it occurs in the bipolar 2,4-dioxo form.

How to Cite
Ukrainets, I. V.; Bereznyakova, N. L.; Petyunin, G. P.; Tugaibei, I. A.; Rybakov, V. B.; Chernyshev, V. V.; Turov, A. V.  Chem. Heterocycl. Compd. 2007, 43, 729. [Khim. Geterotsikl. Soedin. 2007, 864.]

For this article in the English edition see DOI 10.1007/s10593-007-0119-5


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Published

2023-03-01

Issue

No. 6 (2007)

Section

Original Papers