2-PHENACYLBENZOTHIAZOLE IN THE BIGINELLI REACTION

Authors

  • И. Б. Дзвинчук Institute of Organic Chemistry, National Academy of Sciences of Ukraine, 02094 Kie
  • T. B. Макитрук Institute of Organic Chemistry, National Academy of Sciences of Ukraine, 02094 Kie
  • M. O. Лозинский Institute of Organic Chemistry, National Academy of Sciences of Ukraine, 02094 Kie

Keywords:

aldehydes, urea, pyrimidines, thiourea, 2-phenacylbenzothiazoles, Biginelli reaction, cyclocondensation

Abstract

The cyclocondensation of 2-phenacylbenzothiazole with aromatic aldehydes and urea or thiourea in the Biginelli reaction gave previously unreported 4-aryl-5-(2-benzothiazolyl)-2-oxo-6-phenyl-1,2,3,4-tetrahydropyrimidines and their 2-thioxo analogs. An efficient procedure was developed for carrying out the three-component reaction at low temperatures. The structure peculiarities of the products were analyzed using IR, 1H NMR, and X-ray diffraction data.

How to Cite
Dzvinchuk, I. B.; Makitruk, T. V.; Lozinskii, M. O. Chem. Heterocycl. Compd. 2002, 38, 1000. [Khim. Geterotsikl. Soedin. 2002, 1141.]

For this article in the English edition, see DOI https://doi.org/10.1023/A:1020990017914

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Published

2002-08-25

Issue

No. 8 (2002)

Section

Original Papers