SYNTHESIS AND ANTIRADICAL ACTIVITY OF 5-ACETYL-2-ALKYLTHIO-4-ARYL-6-METHYL-1,4-DIHYDROPYRIDINE-3-CARBOXYLIC ACID NITRILES

Authors

  • Д. Тирзите Latvian Institute of Organic Synthesis, Riga LV-1006
  • А. Краузе Latvian Institute of Organic Synthesis, Riga LV-1006
  • А. Зубарева Latvian Institute of Organic Synthesis, Riga LV-1006
  • Г. Тирзитиc Latvian Institute of Organic Synthesis, Riga LV-1006
  • Г. Дубурc Latvian Institute of Organic Synthesis, Riga LV-1006

Keywords:

1,4-dihydropyridines, 1,1-diphenyl-2-picrylhydrazyl, radical cation, trolox, antiradical activity

Abstract

The alkylation of 3-cyano-1,4-dihydropyridine-2(3H)-thiones or the condensation of an aromatic aldehyde, cyanothioacetamide, acetylacetone, and methyl iodide in the presence of piperidine has given a series of novel 5-acetyl-2-alkylthio-4-aryl-6-methyl-1,4-dihydropyridine-3-carboxylic acid nitriles. A compound was obtained from 3,5-di(tert-butyl)-4-hydroxybenzaldehyde in the molecule of which were combined the active part of the antioxidant ionol and a 1,4-dihydropyridine ring. It was found that, among the compounds synthesized, the highest antiradical activity occurred in a compound having two hydroxyl groups in the 4-phenyl substituent.

How to Cite
Tirzite, D.; Krauze, A.; Zubareva, A.; Tirzitis, G.; Duburs, G. Chem. Heterocycl. Compd. 2002, 38, 795. [Khim. Geterotsikl. Soedin. 2002, 902.]

For this article in the English edition, see DOI https://doi.org/10.1023/A:1020625519073

Downloads

Published

2002-07-25

Issue

No. 7 (2002)

Section

Original Papers