ADDITION OF NITRILE OXIDES TO ALLYL ESTERS OF ARYL(HETARYL)CARBOXYLIC ACIDS

Authors

  • В. Дирненс Latvian Institute of Organic Synthesis, Riga LV-1006
  • О. Слядевская Latvian Institute of Organic Synthesis, Riga LV-1006
  • Э. Лукевиц Latvian Institute of Organic Synthesis, Riga LV-1006

Keywords:

isoxazolines, nitrile oxides, hydroxamic acid chlorides

Abstract

3,5-Disubstituted isoxazolines with an aryl(hetaryl) carboxymethyl group in position 5 have been synthesized. The addition reaction of nitrile oxides to allyl esters of aryl(hetaryl) carboxylic acids occurs regiospecifically with the formation of the 5-substituted isomer. Initial pharmacological screening showed that 5-(4-bromobenzoyloxy)methyl-3-(3,4-dimethoxyphenyl)isoxazoline possesses marked nootropic activity.

How to Cite
Dirnens, V.; Slyadevskaya, O.; Lukevics, E. Chem. Heterocycl. Compd. 2002, 38, 434. [Khim. Geterotsikl. Soedin. 2002, 499.]

For this article in the English edition, see DOI https://doi.org/10.1023/A:1016031305715

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Published

2002-04-25

Issue

No. 4 (2002)

Section

Original Papers